Tomb Raider being exclusive to the Xbone doesn't bother me that much since i think it will come to PC eventually, but if the next Mass Effect became a console exclusive (even temporally) I would lose it.
Anything that I backed on Kickstarter because I backed it for PC.... so obviously I'd be upset if they made it console exclusive. I'd demand my money back. For everything else? I really wouldn't care that much. It just means I would never buy that game -- unless years and years down the road when I could pick up a used console for cheap...like bargain bin prices.
Of course the problem with that is that modern consoles have crappy durability.