Okami was the only game I connected deeply enough to care about everything the game offered. The music, art direction and characters combined were enough to make me tear up as I was fighting the final boss.
After losing your powers fighting Yami, the world goes dark and people you met throughout the game realize you were really the sun goddess. They wonder why the sun stopped shining and pray to give Amaterasu the power to defeat Yami. "The Sun Rises" starts to play and even though I heard that song tons of times in MvC3 I teared up. (I never actually beat the game until just this year)