Replaying through Prey over the past week and holy hell, the design of the levels, atmosphere, enemies, weapons, and overall setting are just outlandish and creepy and alien. It creeps me out just playing through some of the game despite that there aren't really any legitimate scary moments. The sad part is, out of all the sci-fi in current gen, this launch FPS has one of the most unique and original tones to it.
Anybody else wish more games would sort of step outside of the box and their comfort zones of standard settings and atmospheres and try more stuff like Prey did?
There's still a good amount of games with pretty creepy aspects. Amnesia, STALKER, Metro 2033, Cryostasis, and Penumbra (which is essentially the predecessor for Amnesia). There's also a few upcoming ones, notably Amnesia: A Machine for Pigs and Routine: http://www.youtube.com/watch?v=d9XrsWUO9sw
Also, Prey wasn't a launch title for the Xbox 360, it came out 8 months after.
"Walking tanks must exist somewhere for there to be such attention to detail like this in mech sim." - IGN Steel Battalion review
If you liked Prey for those reasons, you might want to try clive Barker's Jericho, TC. Now, there was a reason that game had terrible reviews, but if you like games with an old-school vibe and creepy atmosphere that one will do it for you.
It was such a pleasant surprise for me. The gameplay is dated but very fun. For some incredibly strange reason, they even included a hint line that costs money per minute to get help in the game. I remember when almost every game had one of those, not that I'd ever call it. You can probably get Jericho for a couple bucks these days, and its well worth it.