I was playing the Captain Scarlett DLC. On the elevator near Herbert's place, my screen went black once for a second, came back, went black again for a second, then made a small graphic glitch much like you'd see on the original Nintendo. I played another 20 minutes with no further issues.
I have a 250 gig Slim; bought when they first came out. I haven't had other issues. When this happened to me tonight, I had only been playing for 15 minutes or so.
Has anyone experienced this with Borderlands 2 or any other games?