I've heard a few people complaining about GTA V being based in LA. I have a solution that won't cost Rockstar much money and would allow them to make the biggest game ever.
Just copy and paste the Red Dead Redemption map in between every small town in the game and you could easily have: Arkansas, Mississippi, Tennessee, and Alabama. (5 or 6 towns per 'State') Then they could just reuse all of the small towns from GTA V and put around 20 of them in the game with one "large" city at each end of the map.
It's a simple way to create the biggest map ever!
Ryan-06: Fallout 4 deserves the hype. That's a day 1 buy for me. I'll buy 2 PS4 copies of that game when out, and give the other away FREE to one user here!
I think I'll pass on the idea of GTA in the south. London or the U.K., however would be interesting. But, I swear I just read something the other day about a Rockstar employee saying a new game in London probably won't happen in GTA.