Last year there some obvious candidates, but this year..I guess Dishonored will be high on many lists. Hopefully Max Payne 3. Maybe Mass Effect 3..Maybe ZombieU? It could turn out to be a fantastic launch title that blows everyone away. Some might vote Halo 4. It's less obvious this year, more open.
Personally, I wish Max Payne 3. It deserves it. I can't get the game out of my head even half a year later.
-War. War never changes. (Fallout) -War. War has changed. (MGS4)