Phantasy Star, but the older ones. I like the blend of sci-fi and fantasy, and the way that technology seems to be this not-quite-extinct-thing-yet in something like Phantasy Star 4, but it's not exactly featured prominently everywhere. Like, they recognize it for what it is, but the towns and cities are still low-tech.
By the end of the game, you're flying around the solar system in a starship, running around in a landrover, and fighting alongside robots with guns while you charge in with a sword, but the fact that you started out with boomerangs and knives makes it feel that much cooler, to me.
Breath of Fire, Street Fighter, Metal Gear Solid, Final Fantasy, NFL Street(Excluding 3), Castlevania, Guitar/DJ Hero, and Kingdom Hearts.Can't pick just one. Edit: And Dynasty Warriors. Can't forget that.