The ending to MGS3 and MGS4, both brought tears to my eyes. And I guess I can count it for gaming since it happened in the game as a revamped cutscene. But Ultimate tenkaichi when they did the scene with Goku Sacrificing himself by Instant Transmissioning himself and Weighted Imperfect-Cell to King Kais planet. The scene still tears me to pieces.
"We're not tools of the government or anyone else, fighting was the only thing I was good at, but at least I always fought for what I believed in''