The game will be no more a collector's item than every other random game that ever came out is a collector's item. The fact of the matter is that ALL games eventually cease production.
Gamestop a month ago threw something like 300 game titles from their store in a furnace because they no longer sold and they couldn't think of a way to get people to take them. Games like Sky Odyssey or Unison or even Madden 2002 were obliterated. The same theory that Too Human becoming a sudden collector's item would mean that all 300+ of the those titles are pretty much a collector's item too.
So why is everyone so concerned about getting a copy of THIS game now, when they could have picked up the 300+ games Gamestop was getting rid of for a combined price of around $30?
Owner of The NES, SNES, N64, GCN, Wii, SMS, GEN, TG16, PSX, PS2, PS3, XBOX, 360, GB, GBC, GBA SP, GB Micro, DS, DSLite, PSP and a lot of crappy games. --BLINGO!
Theoretically, it could become a collector's item. However, people would really be over estimating how much that really means. Best case scenario, Too Human 2 comes out and it is the greatest game ever and has super devoted die hard fans that absolutely must have a copy of the original Too Human. A near mint copy of Too Human would still only get about $15. Granted, it's much better than the $3 it currently goes for, but it's never going to be a title that goes for more than that.