Pirate or not these issues affect everybody. Not only that but its a bloody documented bug they never got around to fixing.... Here's what the ReadMe says...
Save-Related Error Messages ----------- Below are some error messages that you may see from the game. Please contact customer support if you encounter any of these errors.
01: No save file information. 02: No active world. 03: The save path is empty. 04: Cannot save directory. 05: Cannot find the requested file. 09: Failed to create header record. 10: Failed to write header record. 11: Pre-save callback failure. 12: World file save failure. 13: Post-save callback failure. 14: No load/save manager found. 15: Other error. Sorry.
It's happened to me over a dozen times already, in fact, it just crashed on save just then, hence me loitering in forum 'til I can be bothered restarting the game. However I save every 5-10 minutes. PITA, but at least it prevents major rage. Y'all should maintain 2 saves, I personally have a save file, and another file with an ! at the end, and save alternately. Max loss of time 20 mins.