I'm a bit late at posting - just save money, that is the most important thing. If you keep your wage bill low, after a few weeks you'll be able to start signing some quality players. Also don't be afraid to wheel and deal - if there's an opportunity to make money take it.
Buy a great CB with high Jumping, Bravery and Heading stats, set crossing aim (learn this skill asap) to 6 yard box, and make your DC "challenge GK" (learn this skill too). Centre backs and Strikers are by far the most important positions.
Also, concentrate on getting your tactics right at the beginning, then coaching skills - you'll probably get 2 seasons maximum before the game goes live so ignore Scouting etc. as you'll never need youth.
Buy proven quality players when you can afford it.
Also, buy Karadeniz Gokdeniz if you can - he's a quality player in GW6 and because he's relatively unheard of nobody else knows about him!