I had played Champions Online through beta just fine, but my keyboard started to go bad. I just picked up a "Logitech MX5500 Revolution" Wireless Keyboard and Mouse. All drivers and Logitech software are up to date, and I have no problems with all of the button features outside of the game.
When I got to set the key binds in-game, however, I run into problems.
1. The side-keys on the mouse can not be bound properly. If I pull down the "Special Buttons" list and choose Mouse Click #3, 4, 5 etc. and then click the side buttons, it doesn't activate any of the powers. If I go to set a power and click one of the side buttons, it registers it as the letter "P" or "Q" on the keyboard. How does that work?!?
2. The default key bind for Block is "Shift". When it is set to this default value, I can use Left Shift to activate it. However, if I go to set a power as "Left Shift" (and clicking "Just This" instead of using a Shift + Button combination), the menu will register that Left Shift has been bound, but pressing it won't activate the power.