Whenever I get a little sister and we go gather Adam I end up getting destroyed and then after 4 or 5 tries I rage quit. I need some help when gathering Adam. (Also I'm playing on PC and thought the Xbox board would be more populated)
1) I always tried to go for ones where I can have my back to a wall so I didnt have to worry about enemies coming in from all around me. Not always possible, but do those if you can.
2) If you have Trap Rivets, use them. if you have enough, set them at any access points and then around the corpse you'll be collecting from. they will take care of the first couple of enemies that attack and then the first one or two that make it to the little sister.
3) if you have the Cyclone trap plasmid, set it as a trap as well (may need the level 2 version of it for that, I can't remember)
4) When the traps are all used up and you have to go on the offensive, I'd use Electro Bolt and Winter Blast as my go-to plasmids, and the machine gun (with anti-personnel rounds if you have them) and the shotgun
good luck! --- I do the best Chewbacca impression EVER!