Firstly, I'm new to this game. I've made my favorite combination: Mental and blast hands, but I've heard if you're character is maxed out (in terms of leveling) you will have at least two full weapon loadouts/skills. Does this means that I'll have the option to skill also, let's say two-handed, to the max? Which basically means I'll have the choice to switch between hand blaster and two-handed though out the game?
Well, you shouldn't max out two weapons as it is inefficient. Pick a weapon, get the attacks you need and for the rest of the weapons that you get, just get the attributes that will help for your particular role.
Also, you'll have a lot more than two weapons if you keep playing beyond just getting to lvl 30.
If you want to switch weapons, you can just reset skills --- http://www.last.fm/user/justinra