I actually like the concept of how the Combat Cross was made. The Vampire Killer's base form was made through alchemy, thought it's pretty vague on HOW it was made, then it was fused with the tainted soul of Sara Trantoul to become the Vampire Killer it's known as today.
The Combat Cross seems a bit more detailed in its creation. The Cross itself, according to the game, is an ancient relic that was crafted from the nails used to crucify martyrs (perhaps the Messiah?) while the iron chain was a later addition to the Cross added in by Rinaldo Gandolfi. Each link of the chain was doused in holy water and blessed. A chain with individually blessed links inside of a cross made out of the nails that had been used to crucify martyrs, which may be some of the holiest of men, seems like it's made entirely out of Anti-Evil.
Arguing online is like the Special Olympics: Even if you win, in the end you're still mentally handicapped