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I don't think starting with Flask really replaced starting with Charm or Bead even though it was a viable start for some champions.
Only change is get a Kage's pick instead of HoG and definitely invest in the ruby crystal for aegis or shurelya's early, around 15 minutes.
Kage's doesn't exactly replace HoG as unlike HoG Kage's doesn't give very good stats. In fact Sightstone feels more like a HoG replacement even though it costs only 125 less and grants half of the health. Kage's is probably fine if you can get it but I wouldn't build it every game. Not to mention Kage's builds into more situational items than HoG did even though that Twin Shadow thing is interesting.
I feel like the removal of HoG was one of the biggest changes in season 3 for bot at least and probably one of the main reasons why champions like Kha'zix and Pantheon are creeping into mid to and bot. Back in the day you could survive then retaliate or even Sona ult or something but now they can jump on you from any position and just kill you :(.
I try to get Sightstone, Kage's, and Philosopher's first then boots if I feel like it but otherwise get Aegis. Eventually I'll get Ruby Sightstone, Shurelya's, and Twin Shadows. The game is usually over by then. I do the normal start from S2
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