If you mean hybrid pen runes, don't expect any help/info at all. Many threads have been made about them and the short answer is there is no info on them because no one bothers to try them out.
Everyone simply recommends going either ARpen or Mpen without doing any math/experimenting.
If you mean hybrid as in AD runes+AP runes , the only champ that I know of that had a designated page for that was Akali, and with the latest patch she no longer needs her own page to activate both aspects of her passive. (good news is hybrid pen marks are a good choice for her now)