I'm assuming hybrid pen reds would be the ideal, but I don't own a set and dont plan on buying them, so what is the runner-up? I could see arguments for attack speed or magic pen (or practically anything, really). And which quints? Seems like AP, AS or AD could be good.
And what for jungle? (I'm assuming it's a different setup here.) --- Michael, I did nothing. I did absolutely nothing and it was everything that I thought it could be.~Office Space
though other setups can work too, ad reds on ap kayle aren't terrible because she uses AA's a lot, and that extra ad is nothing to sneeze at. MS quints are useful on mids as it benefits roaming, however kayle does have her heal for extra MS.
you can also do other things like ap blues, and take other quints. Or forego armor yellows and grab some extra mana regen in yellows.
notable runes include:
as reds, ad reds, hybrid pen reds scaling health yellows, armor yellows,mana regen yellows, gp5 yellows ap blues or mr blues AP quints, MS quints, AD quints, AS quints
AS reds and MS quints are probably your best choice for jungle, because they work well and because they are a general jungle page.