I would pop them up at range, Lux would land her Snare and Nidalee would hit her spear. Rinse and repeat until they were low enough and either Kassadin or Yi would nuke them to death.
Between Lux's slow/snare, my slow/knockback/knockup/MS buffs, Kassadin's slow, and Nidalee/Kass/Yi's escapability, no one could close the gap or stick to anyone long enough for a kill. Nid kept everyone healed up and I was able to shield a lot of counter harass.
I can't think of a more OP comp than this --- Resident Zac, Vlad, Malphite, Zed, Irelia, and Rumble player
Mongolian Siege-style, throw Plague-infested minions at their door.
Add Annie and Elise to that.
Pelt your enemy to death with flaming hellbears and gigantic demon spiders!
Oh wait, Syndra can't throw allied things. Damn it Riot, buff the prepubescent void-wench already! --- On the field of honor, the gods bearing witness to my glory, I will pull your entrails through your eyes and use them as reins to ride your soul to hades below!