As much as I liked the fast pacing and definited time limit of Dead Rising, I wouldn't mind if things could be slowed down in DR2, with more of an RPG aspect.
I would like the ability to build a safehouse for people that you rescue throughout the game. You can then acquire materials throughout the area to build up and reinforce your fortifications. Then stockpile food, ammo, medicine, etc.
I could do without the odd cult-aspect this time around, but I still like the idea of having psychos. And based on how the trailer looks, I'm guessing we'll have a larger, more "open" environment to explore.