No. The Mouse and keyboard controls would rape anyone on any console. Besides, its more of a network protocol setup and would be extremely complicated to do so... dont think they would do that with a downloadable game cause it would be expensive.
And while Chrypt22 is correct that the programming side of it makes it difficult, a big reason for the lack of cross-platform gaming is because the console companies want to keep people on their platform rather than giving people options to play with their friends that involve them losing revenue. IMHO it's more business related than tech related, but both are definitely factors.
And yes, us console players would be teh raped anyways :P lol