The glitches only apply to VATs. Why would you use VATs for a sniping? Basically, all VATs does is give you at least a 5% chance to completely miss against a stationary target with an extremely accurate weapon.
The usefulness varies. The YCS/186 with the Meltdown perk can snipe entire groups of enemies. If you are energy weapons only, the YCS/186 is better for sniping really, really tough enemies, but otherwise the Holorifle is better since it one hit kills most enemies when used as a sniper weapon. If you also have guns, you really should be going for a silenced weapon. Even the Sniper Rifle, despite the unimpressive looking damage stat, can one hit kill almost everything, so ultimately a silencer is much better than overkilling an enemy with more damage.