So, I've been considering this for a little while. Explosives are the least used weapon and I think only using explosives would be harder than any other weapon. So, should I give it a run? Advice if I do it? Etc.?
I wouldn't do it on Hardcore and I'd probably do it without companions. No going through the DLC (I have Dead Money, so I could make Gas Bombs in a pinch). I think this might be a lot of fun.
Maybe pre-patch, but post-patched explosives are ridiculous (in the good way).
Killed Lanius with about 3 satchel charges with maxed out explosives.
Anyway, I suggest you do it. It isn't really that hard to start with explosives as dynamite is cheap and plentiful (especially if you hunt down the Powder Gangers for there explosives). Late game, you can slaughter anything with a grenade launcher, Red Glare, Anabelle, etc. Explosives, IMO, is definitely the most fun and entertaining weapon type in the game.
Perks are kinda self-explanatory, You'll want all 3 Demo Experts, Hit the Deck, Mad Bomber, Nuka Chemist (if you want infinite Nuka Grenades), and maybe Splash Damage.
I wouldn't really focus on much VATS perks or a high Agility. Explosives don't really benefit from VATS.
I am going to do this at some point. There are probably going to be some tough parts but I'd bet as you go along you could get pretty good at using mines and retreating to get away from close enemies. Mid-range and long-range you'd own, completely.
Well, once you have some solid defences - power armor and Hit the Deck are the key components of this - you can just fire Thump-Thump shots point-blank and heal the damage off later.
It sounds mental, but the first blast should stun or knock-down anyone who's in your face for long enough to backpedal and finish them off safely. You also get good at shooting grenades at nearby walls so they hurt your enemies a lot and you very little.