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They're different. If you like side-scrolling Beat Em' Ups, go with Comix Zone. If you like high speed gameplay, slashing through your opponents, and one of the best games of the year, go with MGR:R. Also, the price tag is completely different. Wasn't Comic Zone $5 or $6?
PlayStation Network: DarkEmigaru98 Youtube Channel: http://www.youtube.com/user/Emi3280