MGR2 will focus on Raiden teaming up with Michael Wilson to take down terrorists with giant robots who are trying to destroy America. Then they'll combine into Metal Wolf Raiden and fight the members of congress, who have combined using nanomachines (son) into a new type of Metal Gear. The ultimate fight will take place in space, and Metal Wolf Raiden will use the power of the spiral to create the ultimate mecha form: Super Tengen Toppa Orbital Frame Jehuty, which will then have to fight the congressional Super Grand Zamboa, piloted by the ghost of Richard Hawk. There will also be a secret fight with Cyborg Ninja Rodin.
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Snake is revived by nanomachines (son), but instead of injecting the good ones, Doktor accidentally injects the bad ones, and Snake's persona "Dave the Ripper" materializes. You must destroy Dave the Ripper, but not before taking out his posse, The Rippers. You will then get to face Metal Gear George, which came about when Doktor was experimenting with Cyborg/Metal Gear hybrids.