And was blown away when, as I was reading up on some things to see if I'd missed anything, I found out the series was based on a scenario from this game. It seems like the anime series references quite a few things from 428, and might be viewed as a sort of continuation of the events that happened in it. I never would have guessed that on my own, though. I knew a bit about this game and its premise before watching Canaan, but... Not enough to make the distinction, I guess.
For those curious about the scenario Canaan is based on: http://www.youtube.com/watch?v=JOlA5rer1cQ
For those curious about the anime itself: http://www.youtube.com/watch?v=zljyjTh92a8
And whether or not you've played 428, I'd definitely recommend checking Canaan out, especially if you have Netflix. It has some flaws, but IMO, it's a great anime with gorgeous visuals and interesting characters. It was well worth my time.