Vanquish is such a awesome game close to my heart.
We all know Bayonetta 2 is coming to the Wii U, so maybe Vanquish 2 will come to next gen such as PS4 and "X720". I guess P* need to make enough money to fund a sequel to their sublime shooter (or maybe Sony or MS can bankroll it).
I yearn for the return of the wise cracking, chain smoking, boost-dodging Sam!
There may be a slim chance. If you remember the rumours of Bayonetta 2 being cancelled, Kamiya twitted a pic of Bayonetta 2 with Roberts Burns from Vanquish. Sony or MS could make it a timed exclusive. Though a big factor against a sequel happeing it that that main guy behind Vanquish, Shinji Mikami, has left and is now with his new studio Tango Gameworks.
^You pretty much said it yourself. Though Vanquish is also held back by the fact that it doesn't have a big following as Bayonetta or as a big following. Vanquish is more of a cult game so the chances of a sequel are bar none. That said, Bayo2 only happened because Nintendo jumped in to fund it. Sega wasn't interested in it at all, so let stand Vanquish 2.