The main reason why I rallied for the female character skins for C2 is because my wife told me that she'd be much more likely to play the game with me if it did. Her favorite game franchises are Dead Space and Resident Evil, so yeah there are plenty of women that play games.
I tend to think that they don't play with mics most of the time though. There are a lot of jerks online sometimes.
Uncharted 2 Machinima Voice Actor. Currently playing Sully and Lazarevic. Add me on PSN if you want to get involved: Geo_Chronic.