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As with any assault rifle it's good on the Ghost. This gun gets some flak but I actually really like it once you get used to it. It fires slower but has great range and accuracy; some people like a scope on it but I don't. As always make sure you use piercing in some way.
I use it randomly on a number of classes but I don't think that it technically compliments the character. I like it on both the Turian Soldier and Sentinel and I sometimes use it on the Krogan Soldier.
It's one of the worse URs in the game. I would argue the worst after Paladin and Spitfire.
That said, it's not horrible. It relies on headshots to do good damage.. not because it gets a headshot modifier, but because it's damage output is rather low otherwise. This gives it a disadvantage against bosses.
Take an ultralight SMG sidearm, and it serves as a fantastic light sniper rifle. My Turian Sentinel is a great marksman with it. I use Overload to strip shields, Warp to weaken Armor, then collect headshots with the Saber.
Did someone say "Prothean?" This one is familiar with enkindling. This one has enkindled many females across the galaxy.
So because it's a heavier weapon I'd be fine using it on my Destroyer and I have his Devastator mode specced for mag size. I don't know too much about this gun since I missed it in SP and I unlocked it right when I was getting ready to go to work. So I haven't even tried it out yet.
Since it can be used like a sniper rifle, It would be a good investment to put a scope on this right?