Spent 30 minutes putting my Hori Screen Protectors on. Not a single air bubble or dust particle (had to reapply the bottom one once to get rid of a pretty big piece of dust though).
The more pixelated screen will get a little used to, but I guess it's sort of like watching a larger television, just sit a little farther back. I don't have to have the screen so close to my face anymore.
I'm really liking the 3 lock-in positions over the 2 in the 3DS as well. Screen doesn't wobble either. Looks like I just have to break in the circle pad, which seems to be much better constructed.