Metroid Prime

Power Bombs. They kill all 3 Metroids simultaniously. Unfortunately, they respawn infinitely. Be quick and when one is within 4 in-game feet (about the radius of a platform) Morph and drop a power bomb. ALso, they can't use the doors so if you make it to the Missile Station with a few behind you, save your powerbombs and just attack them through the open door. When they split, the Fission Metroids gain a color, and they only take damage from the beam that matches their color after the split. Gold = Power, Violet = Wave, Silver = Ice, Crimson = Plasma. If you use the door trick, they will all be lined up to be exterminated because they want to eat you but can't fit through the door. Once they are gone you have about 30 seconds efore the new generation spawns, so be quick about the movement to the final door of the game. Also, these guys can be good practice for Metroid Prime -- Form 1 due to the weakness rules being the same.