Mass Effect

There are a number of different ways to beat this enemy.
*Note* Destroy all Geth henchmen before working on the Krogan.

1. If your character is a soldier you can repeatedly use immunity to make yourself virtually invincible. Simply shooting the Krogan with your most powerful weapons is all you'll need to do. As a soldier you have the capacity to have infinite Immunity, so it's only a matter of time before you whittle his health to zero.

2. If you're a biotic you can use warp/singularity/stasis in effective combos against the Krogan. If he uses immunity hit him with stasis. When he drops back to normal use warp+any high damage dealing attacks at your disposal.

3. If you'r a tech you will want to work on dropping his shields as fast as possible. Use overload and micro manage your team skills to keep his immunity buff in check. Otherwise it's just damage, damage, damage until he's down.

If you're still having trouble try outfitting your team with as much damage mitigation as possible. His biotics are not near as dangerous as his charge.