Vampires have colonized east of the Mississippi River and have taken all humans hostage. Butch, the last butcher left east of the Mississippi, coincidentally finds out that throwing Steak-umms at vampires makes them explode. Butch hops aboard a train with a load of Steak-umms and heads for freedom: St. Louis Missouri. Butch's adventures take him all over the east coast as he battles vampires and feeds hungry humans along the way. The goal of the game is to travel the 2150 miles from Philadelphia to St. Louis while killing as many vampires and making as much money as possible.