Unlockables

  • Unlock Vampire Wario

    To unlock Vampire Wario as a playable character in Versus mode, complete Story mode on Normal or higher difficulty using Dr. Mario, but without losing a single time.

    Contributed By: ElementalKnight.

  • Unlockable Multi-player characters

    UnlockableHow to Unlock
    Metal MarioComplete Story mode on Normal or higher difficulty using Wario, but without losing a single time.

    Contributed By: Starky27.

Secrets

  • Increase Computer Difficulty

    When selecting a computer opponent in Vs. Computer mode, hold the L button and press A to make his difficulty one star harder (the equivalent of Hard level).

    By holding L and pressing B, the computer player's difficulty increases two stars (the equivalent of S-Hard level).

    Contributed By: ElementalKnight.

  • More Viruses

    To get more Viruses, Press L or R in marathon mode to increase the number of viruses.

    Contributed By: MATT GRAM.

  • S-Hard Difficulty

    To open up S-Hard difficulty in Story mode, highlight Hard and press the Z button. Pressing the Z button again switches it back to Hard.

    Contributed By: ElementalKnight.

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Dr. Mario 64 Resources

Game Rankings

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Game Detail

Dr. Mario 64

Nintendo 64

Titles rated E (Everyone) have content that may be suitable for ages 6 and older.