Blow up the credits
During the ending credits click on any of the text or figures and either Sam or Max will shoot at them.
Contributed By: Fragnarok.
Break Sam's spirit
Attempt to pick up an object that can't be picked up, and try to pick it up multiple times. Each time, Sam will say a different "I can't pick that up" line, until he breaks down and starts crying. Max will yell at you for breaking Sam's "Care-free spirit".
Contributed By: Mario1999.
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