AMY is a survival horror/action adventure game, where players must protect, and escort the eponymous Amy - an enigmatic eight-year-old autistic girl with curious powers - as they try to get her out of a city overrun with wild creatures and dangerous enemies. The story follows Amy and the player character Lana, a woman who is trying to protect and save her in the disease-ridden town. They must work together to fight or flee from the aberrations, demons, and the military, in the hope of saving not only each other, but also the future of humanity itself.