Backbone Entertainment has created a stunning against-all-odds blaster, where four new heroes must attempt to survive a zombie uprising. The quartet is stranded on a remote island which is under siege from an army of the dead. Using whatever weapons come to hand, the player must scour the island looking for survivors and eliminating the flesh-eaters in order to create safe zones.

The action is viewed from an elevated position, with the player central to the action. As the undead attack from all directions, the player uses both control sticks to turn and shoot in all directions, with extra items discarded by fortunate survivors instantly added to an inventory. Zombie Apocalypse: Never Die Alone also introduces a new squad-based mechanism, which allows players to work together. A new class-based system allows users to switch weapons between each other, and also distribute powers and energy to those that need it.