Saints Row: The Third - Enter the Dominatrix picks up immediately following the events of Saints Row: The Third. For centuries, alien warlord Zinyak has eyed Earth and its precious natural resources and females with a watchful eye. As he prepares an armada for invasion, he has only one worry: the Third Street Saints.

Once a simple street gang from Stilwater, the Saints have evolved into a global empire, replete with bombastic TV advertising and tasteful consumer products, the kind of TV advertising and consumer products that would give any alien warlord pause. Clearly, the Saints are the biggest badasses on Earth.

Now, in order to prepare his forces for domination, Zinyak captures the leader of the Saints and imprisons him in an elaborate virtual reality simulation. This simulation program looks and feels like Steelport, but it is the world that has been pulled over your eyes to blind you from the truth. Here, you are a slave. Welcome... to the Dominatrix.