In Comix Zone, Sketch Turner is an artist in New York City. One day Sketch is drawing, and a huge thunderstorm threatens the city. A bolt of lightning hits Sketch's image, and brings it to life. That image is Mortus, a megalomaniac mutant who wants to become real and to rule the earth. Mortus magically transports Sketch into the pages of his comic book so that he can end his creator's life and become real. Inside the comic book, Sketch meets General Alissa Cyan, who believes Sketch is a superhero come to save their post-apocalyptic world from the evil brought by Mortus' hand. Now that he's a comic book superhero, Sketch can instantly fight like a one-man mercenary platoon!