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It was mentioned several times throughout the game, in a few different places, that GF's "Might" cause memory losses, so it really wasn't "Out of nowhere". It was kind of obscure, but it was there.
Not really. It was perhaps mentioned twice at most, and then not hinted at being significant either. It wasn't just 'obscure', it was a lame copout, like something they threw in so they could have an excuse for the twist. It was just handled very poorly.
"You have to be 100% behind someone before you can stab them in the back" ~David Brent.