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They needs to manage the duration on multiple debuffs, but otherwise their whack-a-mole playstyle with no downtime is easy indeed.
Most classes can DPS very easily, Wrath spam with an moonkin, SS strike with a Rogue, FFB spam with a Mage... if you want to maximise DPS, then it changes.
Proper moonkin rotation is Wrath spam till Lunar Eclipse, then Starfire spam until the CD on Lunar Eclipse ends, then repeat. Moonfire and IS needs to be kept up, that should give you maximized DPS. Sadly most moonkins I see just Wrath spams all day long, then whines that they are on the bottom of the chart... no, that is no boomkin, that is OOMkin.
Easiest maximized rotation would be IMO.... Ret Paladin. The only thing that needs to be managed is the 30m seal... once it is up, all remaining DPS abilities are on cooldowns, so you can just key them to 4-5 easy to press buttons and press them in proper order, then simply play whack-a-mole. 1 gets off CD, BEEP! 2 gets off CD, BEEP! 4 gets off CD, BEEP! Roll on loot, and move on.