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Eh. Honestly Nephilim and Demon Hunter are largely the same. Enemies are tuned to hit slightly harder and have marginally more health on Nephilim, but aggression as well as the enemy spawns and the attacks they have are consistent between the two. If you're looking for a challenge, you need to look to Son of Sparda which brings in more high-tier enemies much sooner into the early game, but Son of Sparda also ends up exacerbating the game's design flaws and becomes something of a chore less than a third of the way through.