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What story will it have, besides one part where dante fights vergil again (in your assumptions)? Dante took down virility, and raptor news, releases hell on earth, takes down mundus and his establishment. Now what's next for him in the sequel? Nothing much in my opinion. So where will the sequel start out? And mind you, I'm not asking this as a pro or anti (though I lean on the antis' side).
'm guessing Virgil is going to come back against Dante. Since he doesn't need to hide anymore, he can embrace his demonic side to find aide with the demons in fighting Dante and Kat. I'm sure Dante will get help from both angels and demons for his battle with him.