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Damn, I'm going to have to get this game reserved ASAP after reading the preview. It seems Joel was already "screwed" at the end of the trailer as a gameplay mechanic, if one of the heavier infected 'clickers' bites into you, the game is over (you become a part of the infected.)
Seems the game will certainly be challenging and you probably have to rely on stealth against the more stronger infected. None of that nonsense where you get bit 100 times and you are completely fine.
"A rose best blooms near death. You're in full bloom, pal!" ~ Iori Yagami PSN: LatinChris_9990