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-SINGLE PLAYER!!! -Co-op only included in Mercenaries mode, all campaigns remain single player -Resident Evil 5 controls 'n' camera -All female cast (Jill, Claire, and Sherry) -Mix of Resident Evil 4, Revelations, and Lost in Nightmares game-play style
-Horror -Raid Mode, Battle Mode, Operation Mad Jackal, Leech Hunter -Revelations Style - Jill and Barry, Rebecca and Billy , Hunk campaigns - RE 0 Partner Zapping System - RE 3 style dodging - old RE style inventory system - item boxes or pick and drop mechanic of RE 0