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I thought it was said in some file that Wesker intentionally let the Tyrant gut him because he injected some virus before hand to fake his own death. He probably hates Chris because he killed his creation.
Wesker never intended to let any S.T.A.R.S. members survive the mansion incident and he especially didn't expect to see Tyrant get destroyed. Considering that both Chris's and Jill's campaigns in RE1 are canon I think it's implied that Chris was the one who blew up the Tyrant in canon which really messed up Wesker's plans. His hatred for Chris only grew as time went on as Chris's actions in bringing down Umbrella constantly got him in the way of Wesker's mission for gathering viral research. That's about all I've got regarding Wesker's hatred of Chris lol.
"Why the f*** would I kidnap my own son and pay for you f***ing r****** to find him, you psychotic b****?! Currently OP8 on Borderlands 2.