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One thing I find kind of funny is that in the early builds of Resident Evil 4 (known as Resident Evil 3.5) Leon was actually out to rescue Sherry, but as the game changed it became Ashley. So in that sense their kind of like each other, but not actually the same character.
The blond woman is also wearing an outfit that is surprisingly similar to Ashley's beta outfit in RE4, give some color and design changes: http://img31.imageshack.us/img31/5914/ashleybeta.jpg