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I had a hard time in Leon's campaign for chapters 1 and 2. Chapters 3, 4, and 5 went by a lot easier, and the whole campaign I played on normal mode. I started Jake's chapter 1 on normal mode, and I kept getting destroyed by the Javo and that big guy that you have to fight in the warehouse (I won't attempt spelling his name, let alone pronounce it). I had to turn the difficulty down to amateur, and I still died once in a none QTE.
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Hardest to easiest in my experience; Leon, Chris, Ada, Jake. Didn't die a single time as Jake (Stupid QTE's excluded) and enemies eat too much ammo on Leon and Chris' campaign. Also the PoS zombies in Leon's campaign that are invincible till the game says otherwise was annoying as hell. Ada's was easy too, but I actually had to keep an eye on my ammo seeing as the crossbow only held one at a time.