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Wouldn't it depend on what your build is/what type of character you're RPing?
I LOVE pickpocket if for only the extra pockets perk. Even if I try a build I wouldn't normally do, I've got that ES problem where I like to pick up tons of stuff. carry weight +100, without having to invest heavily in stamina + the steed stone.... AND the poisoned perk. LOVE it.
but like I said, if you're going all paladin or warrior, I can see why those might not matter.
I haven't played as a warrior much, but when I have, a shield with Block perks is amazing. Pickpocketing isn't really useful until you have the thief guild influences but after that it feels pretty cheap.