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So, according to that Niko has a special ability, which would probably make him playable. Guesses on story?
My idea would be that after <spoilers>Kate's death</spoilers> Niko fell into a deep depression (based on his special ability). He also probably has quite a few people who want him dead. So he leaves the sprawl of Liberty City to eke out an existence in North Yankton and to keep away from people. Now, according to that Michael is involved, but I don't know how. Story wise, it seemed like MIchael was finished with crime after the story ends. Roman's involvement could also mean several things (the biggest being his survival being canon). Maybe he goes looking for Niko? Maybe Nike, Roman, and Mallory all shipped up to Yankton?
A place like Los Santos would certainly suit Roman's lifestyle. Maybe he moved to San Andreas and somehow ends up tasking Michael with helping him locate his cousin?
"I want your blood...I want your souls...And I want 'em both, right now." - Johnny Ringo, Tombstone